Global burden of disease and sepsis

The Archivist has seen the impact of Sepsis six and now, Sepsis three with concern about the over use of antibiotics and antimicrobial resistance. Rudd KE et al (Lancet 2020;395(10219):200–211 https://ift.tt/2u7oDUJ] gives us an important reminder about the worldwide seriousness and impact of this devastating disease. The Global Burden of Disease (GBD) is a group of more than 3600 researchers examining health issues from around the world. GBD 2017 reports on 282 underlying causes of death in 195 countries. This group has estimated the global, regional, and national incidence of sepsis and mortality from this disorder using data from this data set. They used the multiple cause-of-death data from 109 million individual death records to calculate mortality related to sepsis. The percentage of sepsis-related deaths by underlying GBD cause in each location worldwide was modelled using mixed-effects linear regression. Sepsis-related mortality for each age group, sex, location, GBD cause,...

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